Flubendiamide フルベンジアミド
Diamides: Act on the receptors in insect muscles (ryanodine receptors). A relatively new class.
In Japan
- Registration
- Registered as a pesticide (first registered February 27, 2007). 13 formulated products contain it.
- Main registered crops
- cabbage, napa cabbage, lettuce, non-heading lettuce (leaf lettuce), edamame, plum and others (83 crop names in the registered uses)
- Toxicity class
- Active ingredient: Ordinary substanceClasses of the 13 formulated products (diluted products sold): ordinary substance 11, deleterious substance 2Classes under Japan's Poisonous and Deleterious Substances Control Act.
- ADI (acceptable daily intake)
- 0.017 mg per kg of body weight per day
- ARfD (acute reference dose)
- 0.15（授乳中の女性） ／ 設定の必要なし（一般の集団） mg per kg of body weight
- Evaluation
- Food Safety Commission of Japan, February 5, 2019
ADI: the amount considered to have no effect on health even if eaten every day for a lifetime. ARfD: the amount considered to have no effect on health when eaten at one time (within 24 hours). Both are set by the Food Safety Commission of Japan, mainly from animal studies.
In Japan's national residue testing (fiscal 2024)
| Produce | Detected / tested | Detection rate | Over the limit |
|---|---|---|---|
| DomesticNo. 8 by detection rate | 22 / 722 | 3.0% | 0 |
| Imported | 10 / 1,251 | 0.8% | 0 |
Found in domestic foods: strawberry, persimmon, eggplant, Welsh onion (including leek), napa cabbage, spinach, apple, cabbage, bok choy (chingensai), tomato, bell pepper, lettuce (including butterhead and chisha lettuce) and others (max. 0.45 ppm)
Found in imported foods: tomato, bell pepper (max. 0.07 ppm)
Tests are counted as pesticide × sample. Any detection counts as “detected” — it does not mean the limit was exceeded. For pesticides outside the top 20, figures are summed from the food-by-food tables of the full report.
Evaluations abroad
- WHO acute toxicity class
- III (Slightly hazardous), LD50 >2000 mg/kgBased on the toxicity of the undiluted active ingredient given once, mainly to rats by mouth (LD50 = the dose that kills half; the smaller, the stronger the acute toxicity). It is not an assessment of the safety of residues in food.
- EU
- Not approved in the EU (approval ended August 2024)EU ADI: 0.017 mg/kg bw/day; ARfD: 0.1 mg/kg bw
- IARC (carcinogenicity)
- No matching entry in the IARC list (not evaluated or out of scope, including Group 3)
Related explainers
Sources
- FAMIC (Food and Agricultural Materials Inspection Center), pesticide registration information (as of Sept. 30, 2026) (Japanese)
- Food Safety Commission of Japan, risk assessment report on Flubendiamide (February 5, 2019) (Japanese)
- MHLW, results of pesticide residue testing in foods, fiscal 2024 (Japanese)
- Consumer Affairs Agency, daily intake survey of pesticide residues in foods, fiscal 2024 (Japanese)
- WHO Recommended Classification of Pesticides by Hazard 2019
- EU Pesticides Database (Flubendiamide)
Last checked 2026-10-01. Registrations and evaluations change over time. This page is a translation of our Japanese page; if they differ, the Japanese page is the reference.