Flufenoxuron フルフェノクスロン
Insect growth regulators (IGRs): Disrupt the way insects grow, such as molting and metamorphosis.
In Japan
- Registration
- Registered as a pesticide (first registered November 8, 1993). 1 formulated product contain it.
- Main registered crops
- apple, Japanese pear, peach, nectarine, small stone fruits, cherry and others (93 crop names in the registered uses)
- Toxicity class
- Active ingredient: Ordinary substanceClasses of the 1 formulated products (diluted products sold): ordinary substance 1Classes under Japan's Poisonous and Deleterious Substances Control Act.
- ADI (acceptable daily intake)
- 0.037 mg per kg of body weight per day
- ARfD (acute reference dose)
- not necessary to set
- Evaluation
- Food Safety Commission of Japan, June 29, 2021
ADI: the amount considered to have no effect on health even if eaten every day for a lifetime. ARfD: the amount considered to have no effect on health when eaten at one time (within 24 hours). Both are set by the Food Safety Commission of Japan, mainly from animal studies.
In Japan's national residue testing (fiscal 2024)
| Produce | Detected / tested | Detection rate | Over the limit |
|---|---|---|---|
| DomesticNo. 14 by detection rate | 68 / 2,615 | 2.6% | 0 |
| Imported | 0 / 2,886 | 0.0% | 0 |
Found in domestic foods: strawberry, edamame, cucumber (including gherkin), kyona (mizuna), komatsuna (Japanese mustard spinach), shungiku (garland chrysanthemum), other vegetables, eggplant, Welsh onion (including leek), spinach, peach, asparagus and others (max. 1.8 ppm)
Tests are counted as pesticide × sample. Any detection counts as “detected” — it does not mean the limit was exceeded. For pesticides outside the top 20, figures are summed from the food-by-food tables of the full report.
In the Consumer Affairs Agency's market basket survey (fiscal 2024; the amount actually taken in from everyday meals), intake was 0.206–0.351% of the ADI.
Evaluations abroad
- WHO acute toxicity class
- III (Slightly hazardous), LD50 >3000 mg/kgBased on the toxicity of the undiluted active ingredient given once, mainly to rats by mouth (LD50 = the dose that kills half; the smaller, the stronger the acute toxicity). It is not an assessment of the safety of residues in food.
- EU
- Not approved in the EUEU ADI: 0.01 mg/kg bw/day; ARfD: —
- IARC (carcinogenicity)
- No matching entry in the IARC list (not evaluated or out of scope, including Group 3)
Related explainers
Sources
- FAMIC (Food and Agricultural Materials Inspection Center), pesticide registration information (as of Sept. 30, 2026) (Japanese)
- Food Safety Commission of Japan, risk assessment report on Flufenoxuron (June 29, 2021) (Japanese)
- MHLW, results of pesticide residue testing in foods, fiscal 2024 (Japanese)
- Consumer Affairs Agency, daily intake survey of pesticide residues in foods, fiscal 2024 (Japanese)
- WHO Recommended Classification of Pesticides by Hazard 2019
- EU Pesticides Database (Flufenoxuron)
Last checked 2026-10-01. Registrations and evaluations change over time. This page is a translation of our Japanese page; if they differ, the Japanese page is the reference.