Penthiopyrad ペンチオピラド

In Japan

Registration

Registered as a pesticide (first registered July 23, 2008). 13 formulated products contain it.

Main registered crops

Western lawn grass, Japanese pear, apple, persimmon, grape, peach and others (82 crop names in the registered uses)

Toxicity class

Active ingredient: Ordinary substance

Classes of the 13 formulated products (diluted products sold): ordinary substance 13

Classes under Japan's Poisonous and Deleterious Substances Control Act.

ADI (acceptable daily intake)

0.081 mg per kg of body weight per day

ARfD (acute reference dose)

1.2 mg per kg of body weight

Evaluation

Food Safety Commission of Japan, December 3, 2025

ADI: the amount considered to have no effect on health even if eaten every day for a lifetime. ARfD: the amount considered to have no effect on health when eaten at one time (within 24 hours). Both are set by the Food Safety Commission of Japan, mainly from animal studies.

In Japan's national residue testing (fiscal 2024)

Found in domestic foods: strawberry, plum (including prune), nira (garlic chives), peach, apple, asparagus, okra, tomato, Japanese pear (max. 0.37 ppm)

Found in imported foods: strawberry, cherry (including cherries), bell pepper (max. 0.53 ppm)

Tests are counted as pesticide × sample. Any detection counts as “detected” — it does not mean the limit was exceeded. For pesticides outside the top 20, figures are summed from the food-by-food tables of the full report.

In the Consumer Affairs Agency's market basket survey (fiscal 2024; the amount actually taken in from everyday meals), intake was 0.029–0.062% of the ADI.

Evaluations abroad

WHO acute toxicity class

III (Slightly hazardous), LD50 >2000 mg/kg

Based on the toxicity of the undiluted active ingredient given once, mainly to rats by mouth (LD50 = the dose that kills half; the smaller, the stronger the acute toxicity). It is not an assessment of the safety of residues in food.

EU

Not approved in the EU (approval ended October 2025)

EU ADI: 0.1 mg/kg bw/day; ARfD: 0.75 mg/kg bw

IARC (carcinogenicity)

No matching entry in the IARC list (not evaluated or out of scope, including Group 3)

Related explainers

• Most and least toxic pesticides, ranked (acute toxicity, ADI, carcinogenicity)
• Does washing, peeling or boiling remove pesticide residues? Measured results
• How are maximum residue limits set? Japan’s positive list system and how much we actually eat

Sources

• FAMIC (Food and Agricultural Materials Inspection Center), pesticide registration information (as of Sept. 30, 2026) (Japanese)
• Food Safety Commission of Japan, risk assessment report on Penthiopyrad (December 3, 2025) (Japanese)
• MHLW, results of pesticide residue testing in foods, fiscal 2024 (Japanese)
• Consumer Affairs Agency, daily intake survey of pesticide residues in foods, fiscal 2024 (Japanese)
• WHO Recommended Classification of Pesticides by Hazard 2019
• EU Pesticides Database (Penthiopyrad)

Last checked 2026-10-01. Registrations and evaluations change over time. This page is a translation of our Japanese page; if they differ, the Japanese page is the reference.

Other SDHI

• Boscalid
• Fluopyram
• Isofetamid
• Fluxapyroxad
• Flutolanil
• Thifluzamide